OPRM1

Across TCGA cell cohorts, OPRM1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OPRM1-associated genes across cancer lineages are PTH, HSFY2, and OR10W1. Each is linked with OPRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRM1-to-partner and partner-to-OPRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by OPRM1-low versus OPRM1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRM1→partner) and Y-score (partner→OPRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTH →	+0.022	+5.196	<.001	.005	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	MC3R →	+0.140	+2.874	<.001	.009	3	1
BLOOD_Lymphoma	TGIF2LY →	+0.087	+3.169	<.001	.008	3	1
BLOOD_Lymphoma	A3GALT2 →	+0.022	+3.021	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PTH by OPRM1 expression — OVARY

Explore this box plot interactively →