OPRL1

Across TCGA pan-cancer cohorts, OPRL1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of OPRL1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where OPRL1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types OPRL1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where OPRL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPRL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.638	<.001	8	view →
HNSC	Male	II,III,IV	+0.412	<.001	7	view →
PDAC	Female	All	+0.736	<.001	6	view →
LSCC	Male	All	−0.451	<.001	6	view →
CCRCC	Male	II,III,IV	+0.233	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

OPRL1–LUAD

Open the LUAD breakdown →