OPRL1

Across TCGA patient cohorts, OPRL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible OPRL1-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Regulated exocytosis, and Semaphorin-plexin signaling pathway. Each is linked with OPRL1 in more than 25 cancer types. Because this analysis shows association rather than direction, both OPRL1-to-partner and partner-to-OPRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by OPRL1-low versus OPRL1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRL1→partner) and Y-score (partner→OPRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of protein localization to nucleus →	+0.063	+0.600	<.001	<.001	3	26
STAD	Regulated exocytosis →	+0.029	+0.401	<.001	<.001	3	26
TGCT	Semaphorin-plexin signaling pathway →	+0.059	+0.562	<.001	<.001	3	26
STAD	Retrograde transport, endosome to Golgi →	+0.035	+0.427	<.001	<.001	3	25
PAAD	Stress fiber assembly →	+0.042	+0.492	<.001	<.001	3	25
STAD	Regulation of Ras protein signal transduction →	+0.039	+0.332	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Regulation of protein localization to nucleus by OPRL1 expression — ESCA

Explore this box plot interactively →