OPRL1

Across TCGA patient cohorts, OPRL1 mutation is significantly associated with the RNA expression of many other genes, with 1,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRL1-associated genes across cancer lineages are RNA5SP247, COX5BP8, and NDUFS5P5. Each is linked with OPRL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPRL1-to-partner and partner-to-OPRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP247 grouped by OPRL1-low versus OPRL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRL1→partner) and Y-score (partner→OPRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP247 →	+0.511	+2.722	<.001	.004	3	3
LUSC	COX5BP8 →	+0.083	+4.511	<.001	<.001	3	3
LUSC	NDUFS5P5 →	+0.193	+3.065	<.001	.003	3	3
LUSC	LINC01392 →	+0.230	+3.186	.005	.002	3	3
LUSC	MIR3664 →	+0.347	+3.566	<.001	.001	3	3
HNSC	OR4C46 →	+0.046	+4.339	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,825 associations by consensus.

RNA5SP247 by OPRL1 expression — LUSC

Explore this box plot interactively →