OPRL1

Across TCGA patient cohorts, OPRL1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRL1-associated genes across cancer lineages are PCNA, ATM, and Cyclin-B1. Each is linked with OPRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRL1-to-partner and partner-to-OPRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OPRL1-low versus OPRL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRL1→partner) and Y-score (partner→OPRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.232	+2.459	.007	.018	3	2
UCEC	ATM →	-0.587	-1.986	.001	.029	3	2
UCEC	Cyclin-B1 →	+0.540	+2.459	.016	.019	3	2
UCEC	A-Raf_pS299 →	-0.163	-2.584	<.001	.010	3	1
UCEC	Gab2 →	+0.334	+1.906	.019	.016	2	2
UCEC	Heregulin →	-0.134	-1.906	.006	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by OPRL1 expression — UCEC

Explore this box plot interactively →