OPRL1

Across TCGA cell cohorts, OPRL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,208 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPRL1-associated GO terms across cancer lineages are G protein-coupled opioid receptor signaling pathway, AMPA glutamate receptor clustering, and Glutamate receptor clustering. Each is linked with OPRL1 in more than 16 cancer types. Because this analysis shows association rather than direction, both OPRL1-to-partner and partner-to-OPRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G protein-coupled opioid receptor signaling pathway grouped by OPRL1-low versus OPRL1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRL1→partner) and Y-score (partner→OPRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	G protein-coupled opioid receptor signaling pathway →	-0.437	-0.535	<.001	.001	3	17
OESOPHAGUS	AMPA glutamate receptor clustering →	+1.165	+1.115	.001	.002	3	12
OESOPHAGUS	Glutamate receptor clustering →	+1.165	+1.115	.001	.002	3	12
OESOPHAGUS	Locomotory exploration behavior →	+0.294	+1.378	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Regulation of sodium ion export across plasma membrane →	-0.222	-0.877	.003	<.001	3	10
LUNG_NSCLC_LUAD	Positive regulation of sodium ion export across plasma membrane →	-0.222	-0.877	.003	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

G protein-coupled opioid receptor signaling pathway by OPRL1 expression — BREAST

Explore this box plot interactively →