OPRL1

Across TCGA cell cohorts, OPRL1 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPRL1-associated genes across cancer lineages are Bromosporine, RVX-208, and GSK2276186C. Each is linked with OPRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRL1-to-partner and partner-to-OPRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bromosporine grouped by OPRL1-low versus OPRL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRL1→partner) and Y-score (partner→OPRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Bromosporine →	+0.394	+2.649	.021	.046	3	1
LARGE_INTESTINE	RVX-208 →	+0.351	+2.646	.023	.047	3	1
LARGE_INTESTINE	GSK2276186C →	+0.541	+2.649	.018	.046	3	1
LARGE_INTESTINE	LMP744 →	+0.754	+2.649	.025	.046	3	1
LARGE_INTESTINE	JNJ38877605 →	+0.346	+2.786	.047	.037	3	1
LARGE_INTESTINE	KIN001-236 →	+0.344	+2.652	.016	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Bromosporine by OPRL1 expression — LARGE_INTESTINE

Explore this box plot interactively →