OPRK1

Across TCGA patient cohorts, OPRK1 mutation is significantly associated with the RNA expression of many other genes, with 2,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRK1-associated genes across cancer lineages are ZNF367, UQCRH, and YRDC. Each is linked with OPRK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OPRK1-to-partner and partner-to-OPRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by OPRK1-low versus OPRK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRK1→partner) and Y-score (partner→OPRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZNF367 →	+0.418	+3.062	.007	<.001	3	4
SKCM	UQCRH →	+0.355	+1.542	.001	.001	3	4
SKCM	YRDC →	+0.346	+2.147	.001	<.001	3	4
SKCM	PRC1 →	+0.496	+2.047	.001	.001	3	4
UCEC	PBK →	+0.735	+2.010	.004	.001	3	4
UCEC	FANCI →	+0.478	+3.470	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,531 associations by consensus.

ZNF367 by OPRK1 expression — SKCM

Explore this box plot interactively →