OPRK1

Across TCGA patient cohorts, OPRK1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRK1-associated genes across cancer lineages are 4E-BP1, Bax, and Caspase-7-cleavedD198. Each is linked with OPRK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPRK1-to-partner and partner-to-OPRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OPRK1-low versus OPRK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRK1→partner) and Y-score (partner→OPRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.254	+1.502	.010	.030	3	3
SKCM	Bax →	-0.192	-2.070	.015	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.635	+2.135	.003	.010	3	2
UCEC	cIAP →	+0.105	+1.594	.038	.042	3	2
SKCM	ACC_pS79 →	+0.241	+1.874	.016	.047	3	1
SKCM	p38-MAPK →	-0.123	-2.321	.038	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1 by OPRK1 expression — UCEC

Explore this box plot interactively →