OPRK1

Across TCGA cell cohorts, OPRK1 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPRK1-associated genes across cancer lineages are RETN, RTP1, and KRTAP22-2. Each is linked with OPRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRK1-to-partner and partner-to-OPRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETN grouped by OPRK1-low versus OPRK1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRK1→partner) and Y-score (partner→OPRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RETN →	+0.056	+3.345	.001	.007	3	1
SKIN	RTP1 →	+0.006	+4.518	.001	<.001	3	1
SKIN	KRTAP22-2 →	+0.083	+4.022	<.001	.006	3	1
SKIN	PRSS41 →	+0.052	+3.347	<.001	.005	3	1
LARGE_INTESTINE	C1QBP →	+0.834	+3.131	<.001	.008	3	1
LARGE_INTESTINE	WARS2 →	+0.488	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

RETN by OPRK1 expression — SKIN

Explore this box plot interactively →