OPRK1

Across TCGA cell cohorts, OPRK1 mutation is significantly associated with the mutation status of many other genes, with 2,386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPRK1-associated genes across cancer lineages are ATRN, ADGRV1, and ENTPD8. Each is linked with OPRK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPRK1-to-partner and partner-to-OPRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATRN grouped by OPRK1-low versus OPRK1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRK1→partner) and Y-score (partner→OPRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATRN →	+3.532	+3.357	.005	.005	1	3
BLOOD_Leukemia	ADGRV1 →	+1.607	+3.538	.009	.009	1	3
CNS	ENTPD8 →	+6.044	+6.044	.001	.001	1	3
LARGE_INTESTINE	ZNF483 →	+2.886	+2.407	.008	.008	1	3
LARGE_INTESTINE	UNC5C →	+2.471	+2.369	.005	.005	1	3
LARGE_INTESTINE	COL27A1 →	+1.578	+2.185	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,386 associations by consensus.

ATRN by OPRK1 expression — SKIN

Explore this box plot interactively →