OPN3

Across TCGA pan-cancer cohorts, OPN3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated OPN3 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OPN3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OPN3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where OPN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.939	0.454	.004	17	view →
LUAD	DFS	Median	III,IV	0.542	0.913	.038	3	view →
HNSC	DFS	Median	All	0.526	0.981	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

OPN3–LSCC (DFS)

Open the LSCC breakdown →