OPN3

Across TCGA patient cohorts, OPN3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,069 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OPN3-associated genes across cancer lineages are SKA1, CDC25A, and PBK. Each is linked with OPN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both OPN3-to-partner and partner-to-OPN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OPN3 versus SKA1 in GBM, with a Pearson correlation of 0.86.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN3→partner) and Y-score (partner→OPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKA1 →	+1.223	+0.983	<.001	<.001	3	5
GBM	CDC25A →	+1.214	+0.973	<.001	<.001	3	4
LUAD	PBK →	+1.876	+1.810	.004	.001	3	4
LUAD	AURKA →	+1.263	+0.964	.001	.004	3	4
UCEC	CDKN3 →	+1.589	+1.626	<.001	.001	3	4
LSCC	VRK1 →	+0.942	+1.148	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,069 associations by consensus.

OPN3 vs SKA1 — GBM

Explore this scatter interactively →