OPN3

Across TCGA patient cohorts, OPN3 mutation is significantly associated with the RNA expression of many other genes, with 589 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN3-associated genes across cancer lineages are RNU6-537P, RNU6-879P, and MTND2P19. Each is linked with OPN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPN3-to-partner and partner-to-OPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-537P grouped by OPN3-low versus OPN3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN3→partner) and Y-score (partner→OPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-537P →	+0.173	+4.444	<.001	.006	3	3
HNSC	RNU6-879P →	+0.455	+4.952	<.001	.002	3	2
LUAD	MTND2P19 →	+0.072	+5.410	<.001	.005	3	2
LUAD	KIR3DP1 →	+0.305	+6.444	<.001	.001	3	2
UCEC	MIR3661 →	+0.754	+2.157	<.001	.007	3	2
SKCM	RN7SL680P →	+0.227	+5.634	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 589 associations by consensus.

RNU6-537P by OPN3 expression — BLCA

Explore this box plot interactively →