OPN3

Across TCGA patient cohorts, OPN3 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN3-associated genes across cancer lineages are CD4+ memory T-cells, mv Endothelial cells, and lymphatic Endothelial cells. Each is linked with OPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN3-to-partner and partner-to-OPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ memory T-cells grouped by OPN3-low versus OPN3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN3→partner) and Y-score (partner→OPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD4+ memory T-cells →	+0.013	+2.543	.042	.035	3	1
UCEC	mv Endothelial cells →	-0.024	-2.574	.029	.011	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-2.959	.046	.036	2	1
UCEC	Endothelial cells →	-0.041	-3.657	.021	.001	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD4+ memory T-cells by OPN3 expression — COAD

Explore this box plot interactively →