OPN1SW

Across TCGA patient cohorts, OPN1SW mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN1SW-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with OPN1SW in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN1SW-to-partner and partner-to-OPN1SW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OPN1SW-low versus OPN1SW-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN1SW→partner) and Y-score (partner→OPN1SW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.358	+2.415	.014	.003	3	1
UCEC	Notch1 →	+0.158	+2.125	.005	.010	3	1
UCEC	p62 Lck ligand →	+0.277	+1.906	.034	.016	2	2
UCEC	STAT3_pY705 →	-0.329	-1.990	.001	.030	3	1
UCEC	Bap1-c-4 →	+0.175	+3.479	.047	.002	3	1
UCEC	4E-BP1_pT37_T46 →	-0.394	-2.308	.009	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by OPN1SW expression — UCEC

Explore this box plot interactively →