OPLAH

Across TCGA pan-cancer cohorts, OPLAH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OPLAH data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OPLAH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OPLAH expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where OPLAH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	1.000	0.840	.038	12	view →
CCRCC	OS	Quartile	II,III,IV	0.977	0.104	.036	12	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
OV	DFS	Median	All	0.870	1.000	.046	4	view →
HNSC	DFS	Tertile	II,III,IV	0.719	0.907	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OPLAH–COAD (DFS)

Open the COAD breakdown →