OPLAH

Across TCGA patient cohorts, OPLAH mutation is significantly associated with the RNA expression of many other genes, with 4,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPLAH-associated genes across cancer lineages are CENPE, ZWILCH, and SKA1. Each is linked with OPLAH in more than 4 cancer types. Because this analysis shows association rather than direction, both OPLAH-to-partner and partner-to-OPLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPE grouped by OPLAH-low versus OPLAH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPLAH→partner) and Y-score (partner→OPLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPE →	+0.708	+3.595	<.001	.001	3	5
SKCM	ZWILCH →	+0.525	+2.106	.007	.003	3	4
UCEC	SKA1 →	+0.695	+3.828	<.001	<.001	3	4
UCEC	C18orf54 →	+0.753	+2.392	<.001	<.001	3	4
SKCM	DEPDC1 →	+0.721	+2.093	.004	.003	3	4
UCEC	SPAG5 →	+0.629	+2.392	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

CENPE by OPLAH expression — COAD

Explore this box plot interactively →