OPLAH

Across TCGA patient cohorts, OPLAH mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPLAH-associated genes across cancer lineages are Caspase-7-cleavedD198, VEGFR2, and IGFBP2. Each is linked with OPLAH in more than 2 cancer types. Because this analysis shows association rather than direction, both OPLAH-to-partner and partner-to-OPLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OPLAH-low versus OPLAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPLAH→partner) and Y-score (partner→OPLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.643	+2.341	.007	.019	3	3
SKCM	VEGFR2 →	-0.255	-3.000	.049	.035	3	2
UCEC	IGFBP2 →	-0.612	-2.321	.019	.034	3	2
COAD	JNK_pT183_Y185 →	-0.233	-2.982	.022	.034	3	2
COAD	Rad50 →	-0.401	-3.459	<.001	.004	3	2
COAD	ATM →	-0.586	-2.106	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by OPLAH expression — UCEC

Explore this box plot interactively →