OPLAH

Across TCGA cell cohorts, OPLAH mutation is significantly associated with the RNA expression of many other genes, with 2,061 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPLAH-associated genes across cancer lineages are DAO, TTK, and GRSF1. Each is linked with OPLAH in more than 1 cancer types. Because this analysis shows association rather than direction, both OPLAH-to-partner and partner-to-OPLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAO grouped by OPLAH-low versus OPLAH-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPLAH→partner) and Y-score (partner→OPLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DAO →	+0.034	+4.491	<.001	.002	3	2
BLOOD_Leukemia	TTK →	+0.777	+3.351	.002	.003	3	2
LARGE_INTESTINE	GRSF1 →	+0.643	+3.252	<.001	.002	3	2
BLOOD_Leukemia	GABPB2 →	+1.023	+3.351	<.001	.003	3	2
LARGE_INTESTINE	GATAD2B →	+0.600	+2.389	<.001	.006	3	2
CNS	SPACA1 →	+0.066	+5.754	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,061 associations by consensus.

DAO by OPLAH expression — KIDNEY

Explore this box plot interactively →