Across TCGA patient cohorts, OPCML protein abundance is significantly associated with the RNA expression of many other genes, with 5,273 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OPCML-associated genes across cancer lineages are YPEL1, SNRPD3, and GGT1. Each is linked with OPCML in more than 1 cancer types. Because this analysis shows association rather than direction, both OPCML-to-partner and partner-to-OPCML results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPCML→partner) and Y-score (partner→OPCML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.571	+0.671	.001	<.001	3	1
GBM	SNRPD3 →	+0.455	+0.732	<.001	<.001	3	1
GBM	GGT1 →	+0.175	+0.467	.002	.008	3	1
GBM	PRODH →	+0.910	+0.672	.001	<.001	3	1
GBM	GRK3 →	+0.467	+0.474	<.001	<.001	3	1
GBM	SEZ6L →	+2.023	+0.668	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,273 associations by consensus.

Exploration

OPCML survival (RNA) · tumor vs normal (RNA) · all OPCML data types