Across TCGA patient cohorts, OPCML mutation is significantly associated with the RNA expression of many other genes, with 4,862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPCML-associated genes across cancer lineages are MIR1911, GOT1, and COX15. Each is linked with OPCML in more than 3 cancer types. Because this analysis shows association rather than direction, both OPCML-to-partner and partner-to-OPCML results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPCML→partner) and Y-score (partner→OPCML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR1911 →	+0.414	+3.143	<.001	.008	3	4
COAD	GOT1 →	+0.518	+3.472	<.001	.002	3	4
COAD	COX15 →	+0.424	+3.472	<.001	.002	3	4
UCEC	RRM2 →	+0.757	+1.669	<.001	<.001	3	4
UCEC	GNPNAT1 →	+0.534	+1.513	<.001	<.001	3	4
UCEC	EMC9 →	+0.277	+1.869	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,862 associations by consensus.

Exploration

OPCML survival (RNA) · tumor vs normal (RNA) · all OPCML data types