Across TCGA cell cohorts, OPCML mutation is significantly associated with the RNA expression of many other genes, with 124 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPCML-associated genes across cancer lineages are CCR8, PAPLN, and RSPH6A. Each is linked with OPCML in more than 1 cancer types. Because this analysis shows association rather than direction, both OPCML-to-partner and partner-to-OPCML results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPCML→partner) and Y-score (partner→OPCML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LARGE_INTESTINE	PAPLN →	+0.846	+3.299	.001	.004	3	1
LARGE_INTESTINE	RSPH6A →	+0.136	+3.129	<.001	.001	3	1
LARGE_INTESTINE	AKAP3 →	+0.678	+3.212	.009	.006	3	1
LARGE_INTESTINE	HINT3 →	+0.835	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CTBS →	+0.770	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 124 associations by consensus.

Exploration

OPCML survival (RNA) · tumor vs normal (RNA) · all OPCML data types