Across TCGA patient cohorts, OPALIN mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPALIN-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and PAI-1. Each is linked with OPALIN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPALIN-to-partner and partner-to-OPALIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPALIN→partner) and Y-score (partner→OPALIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.215	-3.169	.008	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.837	-3.169	<.001	.019	3	1
UCEC	PAI-1 →	+0.388	+3.000	.039	.036	3	1
UCEC	PDCD4 →	-1.109	-3.169	<.001	.018	3	1
UCEC	PKC-b-II_pS660 →	-0.365	-3.169	.016	.020	3	1
UCEC	p62 Lck ligand →	+0.626	+3.169	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

OPALIN survival (RNA) · tumor vs normal (RNA) · all OPALIN data types