Across TCGA pan-cancer cohorts, OPA1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OPA1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OPA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OPA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, LIHC, and SARC are the cancer types where OPA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
LIHC	DFS	Median	All	0.240	0.547	<.001	9	view →
SARC	DFS	Median	All	0.109	0.611	.030	6	view →
UCEC	DFS	Median	All	0.959	0.618	.017	6	view →
STAD	DFS	Median	All	0.198	0.587	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: OPA1 tumor-vs-normal RNA expression · all OPA1 data types