Across TCGA patient cohorts, OPA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,193 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible OPA1-associated proteins across cancer lineages are PAK2, ABCF3, and FXR1. Each is linked with OPA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAK2 →	+0.259	+0.447	<.001	.002	3	9
LSCC	ABCF3 →	+0.395	+0.806	<.001	<.001	3	7
LSCC	FXR1 →	+0.487	+0.788	<.001	<.001	3	7
LSCC	GMPS →	+0.466	+0.710	<.001	<.001	3	7
LSCC	UBXN7 →	+0.633	+0.961	<.001	<.001	3	7
HNSC	TBL1XR1 →	+0.485	+0.771	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,193 associations by consensus.

Exploration

OPA1 survival (RNA) · tumor vs normal (RNA) · all OPA1 data types