Across TCGA patient cohorts, OPA1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,354 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible OPA1-associated genes across cancer lineages are NDUFB5, GFM1, and NCBP2AS2. Each is linked with OPA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NDUFB5 →	+0.735	+0.569	<.001	.001	3	6
HNSC	GFM1 →	+0.579	+0.219	<.001	<.001	3	6
HNSC	NCBP2AS2 →	+1.068	+0.324	<.001	<.001	3	6
LSCC	TMEM41A →	+0.697	+0.460	<.001	<.001	3	6
LSCC	SENP2 →	+0.783	+0.529	<.001	<.001	3	6
LSCC	DLG1 →	+0.846	+0.457	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,354 associations by consensus.

Exploration

OPA1 survival (RNA) · tumor vs normal (RNA) · all OPA1 data types