Across TCGA patient cohorts, OPA1 mutation is significantly associated with the RNA expression of many other genes, with 2,618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPA1-associated genes across cancer lineages are MTCYBP38, LINC01853, and LINC01072. Each is linked with OPA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTCYBP38 →	+0.049	+4.623	<.001	.001	3	3
LUAD	LINC01853 →	+0.210	+4.303	<.001	.009	3	3
LUAD	LINC01072 →	+0.160	+3.962	.002	.005	3	3
UCEC	RNA5SP167 →	+0.222	+3.186	<.001	.003	3	3
UCEC	RNA5SP411 →	+0.934	+1.978	<.001	<.001	3	2
BLCA	RNU6-1186P →	+0.106	+4.463	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,618 associations by consensus.

Exploration

OPA1 survival (RNA) · tumor vs normal (RNA) · all OPA1 data types