Across TCGA patient cohorts, OPA1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPA1-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC1, and INPP4B. Each is linked with OPA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.720	.007	.003	3	3
UCEC	ACC1 →	+0.333	+1.750	.014	.049	3	2
UCEC	INPP4B →	-0.329	-2.415	.006	.003	3	2
UCEC	PCNA →	+0.220	+2.459	.006	.018	3	2
BLCA	Cyclin-D1 →	-0.238	-3.169	.021	.019	3	1
BLCA	DJ-1 →	-0.166	-3.135	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

OPA1 survival (RNA) · tumor vs normal (RNA) · all OPA1 data types