Across TCGA cell cohorts, OPA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,721 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OPA1-associated GO terms across cancer lineages are Replication fork processing, DNA-templated DNA replication maintenance of fidelity, and Ribosome localization. Each is linked with OPA1 in more than 15 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Replication fork processing →	+0.114	+1.045	<.001	<.001	3	16
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.125	+0.929	<.001	.002	3	15
SKIN	Ribosome localization →	+0.129	+0.652	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.159	+0.945	<.001	.002	3	14
SKIN	Ribosomal subunit export from nucleus →	+0.129	+0.652	<.001	<.001	3	14
BLOOD_Myeloma	Double-strand break repair →	+0.074	+0.854	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,721 associations by consensus.

Exploration

OPA1 survival (RNA) · tumor vs normal (RNA) · all OPA1 data types