OPA1

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, OPA1 mutation is significantly associated with the RNA expression of many other genes, with 944 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPA1-associated genes across cancer lineages are IQCF5, C1orf189, and FTHL17. Each is linked with OPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPA1-to-partner and partner-to-OPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA1→partner) and Y-score (partner→OPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UPPER_AERODIGESTIVE_TRACTIQCF5 →+0.056+5.357<.001.00332
BLOOD_LeukemiaC1orf189 →+0.167+3.736<.001.00532
LUNG_NSCLC_LUADFTHL17 →+1.367+2.959<.001.00432
LARGE_INTESTINEMTF2 →+0.663+3.067.001.00932
LARGE_INTESTINEMCHR2 →+0.011+2.614.005.00132
LARGE_INTESTINECATSPER4 →+0.040+3.951.009<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 944 associations by consensus.

Exploration