OOSP2

Across TCGA pan-cancer cohorts, OOSP2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OOSP2 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher OOSP2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OOSP2 expression acts as an unfavorable survival marker.

ESCA, LUAD, and LUSC are the cancer types where OOSP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
LUAD	OS	Median	III,IV	0.068	0.680	<.001	18	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.124	0.344	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OOSP2–ESCA (OS)

Open the ESCA breakdown →