Across TCGA pan-cancer cohorts, OOEP Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OOEP data layer compared with 23 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OOEP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OOEP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
HNSC, BLCA, and LUSC are the cancer types where OOEP Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.