Across TCGA patient cohorts, OOEP mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OOEP-associated genes across cancer lineages are ATM, SCD, and c-Kit. Each is linked with OOEP in more than 2 cancer types. Because this analysis shows association rather than direction, both OOEP-to-partner and partner-to-OOEP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OOEP→partner) and Y-score (partner→OOEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.447	-2.459	.041	.020	3	2
UCEC	SCD →	+0.139	+3.013	.009	.018	3	1
UCEC	c-Kit →	-0.231	-2.459	.040	.020	3	1
UCEC	Cyclin-B1 →	+0.603	+2.459	.026	.020	1	3
UCEC	Notch1 →	+0.282	+3.584	<.001	.002	1	2
UCEC	PCNA →	+0.274	+3.584	.008	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

OOEP survival (RNA) · tumor vs normal (RNA) · all OOEP data types