OOEP-AS1

Across TCGA pan-cancer cohorts, OOEP-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated OOEP-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher OOEP-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OOEP-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

LIHC, ACC, and READ are the cancer types where OOEP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.473	0.708	<.001	87	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	42	view →
READ	OS	Tertile	III,IV	0.111	0.890	<.001	36	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	36	view →
DLBC	OS	Tertile	All	0.380	0.875	<.001	27	view →
THYM	OS	Tertile	II,III,IV	0.852	0.985	.009	18	view →
LUAD	OS	Tertile	IV	0.237	0.687	.009	18	view →
KIRC	DFS	Tertile	All	0.463	0.658	.027	18	view →
HNSC	OS	Tertile	All	0.755	0.641	.028	15	view →
CESC	DFS	Tertile	All	0.654	0.771	.032	12	view →
SKCM	DFS	Tertile	All	0.731	0.584	.013	6	view →
LUSC	DFS	Tertile	II,III,IV	0.534	0.791	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

OOEP-AS1–LIHC (OS)

Open the LIHC breakdown →