Across TCGA pan-cancer cohorts, ONECUT3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated ONECUT3 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ONECUT3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ONECUT3 expression acts as an unfavorable survival marker.

THYM are the cancer types where ONECUT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.068	0.977	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: ONECUT3 tumor-vs-normal RNA expression · all ONECUT3 data types