Across TCGA patient cohorts, ONECUT3 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ONECUT3-associated genes across cancer lineages are RPL23AP72, RNU7-29P, and MTND1P35. Each is linked with ONECUT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ONECUT3-to-partner and partner-to-ONECUT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT3→partner) and Y-score (partner→ONECUT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL23AP72 →	+0.366	+4.415	<.001	.006	3	2
BRCA	RNU7-29P →	+0.395	+8.055	<.001	.007	3	1
BRCA	MTND1P35 →	+0.059	+7.731	<.001	.009	3	1
BRCA	MIR4643 →	+0.341	+7.731	<.001	.009	3	1
BRCA	MIR3689D1 →	+0.359	+9.057	<.001	.003	3	1
UCEC	OR5I1 →	+0.058	+5.226	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

ONECUT3 survival (RNA) · tumor vs normal (RNA) · all ONECUT3 data types