Across TCGA cell cohorts, ONECUT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 968 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ONECUT3-associated GO terms across cancer lineages are Positive regulation of hydrogen peroxide biosynthetic process, DNA damage response, signal transduction by p53 class mediator, and Negative regulation of Notch signaling pathway. Each is linked with ONECUT3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ONECUT3-to-partner and partner-to-ONECUT3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT3→partner) and Y-score (partner→ONECUT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of hydrogen peroxide biosynthetic process →	-0.119	-0.739	<.001	.003	3	4
STOMACH	DNA damage response, signal transduction by p53 class mediator →	+0.062	+2.763	.009	<.001	3	4
STOMACH	Negative regulation of Notch signaling pathway →	+0.079	+2.998	<.001	<.001	3	4
STOMACH	Positive regulation of chondrocyte proliferation →	+0.245	+2.481	<.001	<.001	3	3
LUNG_NSCLC_LUAD	Integrin activation →	-0.144	-0.907	<.001	.002	3	3
LUNG_NSCLC_LUAD	Cortisol metabolic process →	+0.684	+0.781	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 968 associations by consensus.

Exploration

ONECUT3 survival (RNA) · tumor vs normal (RNA) · all ONECUT3 data types