ONECUT2

Across TCGA pan-cancer cohorts, ONECUT2 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ONECUT2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ONECUT2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ONECUT2 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC are the cancer types where ONECUT2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ONECUT2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.685	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

ONECUT2–HNSC

Open the HNSC breakdown →