ONECUT1

Across TCGA patient cohorts, ONECUT1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ONECUT1-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and PEA-15_pS116. Each is linked with ONECUT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ONECUT1-to-partner and partner-to-ONECUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ONECUT1-low versus ONECUT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT1→partner) and Y-score (partner→ONECUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.457	+1.720	.026	.025	3	3
UCEC	PCNA →	+0.280	+2.222	<.001	.009	3	2
UCEC	PEA-15_pS116 →	+0.317	+2.222	.009	.009	3	2
UCEC	TIGAR →	+0.149	+2.096	.004	.001	3	2
UCEC	Bax →	+0.225	+1.688	.006	.013	3	2
UCEC	EGFR_pY1068 →	-0.225	-1.678	.009	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by ONECUT1 expression — UCEC

Explore this box plot interactively →