ONECUT1

Across TCGA cell cohorts, ONECUT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,936 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ONECUT1-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Regulation of DNA repair, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with ONECUT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ONECUT1-to-partner and partner-to-ONECUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ONECUT1-low versus ONECUT1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT1→partner) and Y-score (partner→ONECUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.035	+0.228	.003	.007	3	7
BREAST	Regulation of DNA repair →	+0.048	+0.419	.002	.006	2	7
KIDNEY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.115	+0.167	<.001	<.001	3	6
CNS	RNA splicing, via transesterification reactions →	+0.028	+0.461	.005	.001	3	6
CNS	Nuclear export →	+0.045	+0.510	.002	.006	3	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.054	+0.409	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

Epigenetic regulation of gene expression by ONECUT1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →