ONECUT1

Across TCGA cell cohorts, ONECUT1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ONECUT1-associated genes across cancer lineages are PRKACG, SMR3B, and RXFP3. Each is linked with ONECUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ONECUT1-to-partner and partner-to-ONECUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by ONECUT1-low versus ONECUT1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT1→partner) and Y-score (partner→ONECUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRKACG →	+0.027	+4.169	<.001	.008	3	1
CNS	SMR3B →	+1.332	+4.472	<.001	.004	3	1
CNS	RXFP3 →	+0.044	+4.169	.001	.008	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRKACG by ONECUT1 expression — CNS

Explore this box plot interactively →