ONECUT1

Across TCGA cell cohorts, ONECUT1 mutation is significantly associated with the mutation status of many other genes, with 3,043 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ONECUT1-associated genes across cancer lineages are GRM7, TSC22D1, and SLC12A4. Each is linked with ONECUT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ONECUT1-to-partner and partner-to-ONECUT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM7 grouped by ONECUT1-low versus ONECUT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT1→partner) and Y-score (partner→ONECUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GRM7 →	+3.390	+5.080	<.001	<.001	1	4
BLOOD_Lymphoma	TSC22D1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	SLC12A4 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	DGKQ →	+5.014	+5.584	.003	.003	1	4
BLOOD_Leukemia	ANK1 →	+3.753	+5.347	<.001	<.001	1	4
BLOOD_Leukemia	LMTK3 →	+3.145	+3.932	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,043 associations by consensus.

GRM7 by ONECUT1 expression — BLOOD_Leukemia

Explore this box plot interactively →