OMP

Across TCGA patient cohorts, OMP mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OMP-associated genes across cancer lineages are SNORD111B, RNU6-718P, and LINC02339. Each is linked with OMP in more than 1 cancer types. Because this analysis shows association rather than direction, both OMP-to-partner and partner-to-OMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD111B grouped by OMP-low versus OMP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OMP→partner) and Y-score (partner→OMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNORD111B →	+0.802	+3.754	.004	.008	3	2
UCEC	RNU6-718P →	+0.279	+4.555	<.001	.005	3	2
SKCM	LINC02339 →	+0.109	+6.080	.001	.002	3	1
HNSC	RNU6-1159P →	+0.403	+7.954	<.001	.008	3	1
SKCM	OR51I2 →	+0.053	+5.867	<.001	.003	3	1
SKCM	SMIM11P1 →	+0.246	+4.979	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

SNORD111B by OMP expression — COAD

Explore this box plot interactively →