OMG

Across TCGA patient cohorts, OMG protein abundance is significantly associated with the RNA expression of many other genes, with 9,183 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OMG-associated genes across cancer lineages are PRODH, GRK3, and LGALS1. Each is linked with OMG in more than 1 cancer types. Because this analysis shows association rather than direction, both OMG-to-partner and partner-to-OMG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OMG versus PRODH in GBM, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OMG→partner) and Y-score (partner→OMG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.710	+0.705	.003	<.001	3	1
GBM	GRK3 →	+0.496	+0.906	<.001	<.001	3	1
GBM	LGALS1 →	-0.756	-0.958	.003	.001	3	1
GBM	PIK3IP1 →	+0.473	+0.610	.002	.001	3	1
GBM	POLR2F →	+0.378	+0.725	.003	.002	3	1
GBM	SOX10 →	+1.368	+0.979	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,183 associations by consensus.

OMG vs PRODH — GBM

Explore this scatter interactively →