OMD

Across TCGA pan-cancer cohorts, OMD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OMD data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OMD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OMD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where OMD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.572	0.834	<.001	53	view →
CCRCC	DFS	Quartile	II,III,IV	0.778	0.249	.004	8	view →
GBM	DFS	Quartile	All	0.630	0.861	.006	7	view →
LUAD	DFS	Median	All	0.958	0.877	.007	4	view →
HNSC	DFS	Tertile	III,IV	0.904	0.745	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OMD–LSCC (DFS)

Open the LSCC breakdown →