OMD

Across TCGA patient cohorts, OMD mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OMD-associated genes across cancer lineages are RNY3P7, PGBD4P2, and MAT1A. Each is linked with OMD in more than 1 cancer types. Because this analysis shows association rather than direction, both OMD-to-partner and partner-to-OMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P7 grouped by OMD-low versus OMD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OMD→partner) and Y-score (partner→OMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNY3P7 →	+0.248	+4.595	<.001	.004	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
UCEC	MAT1A →	-1.129	-3.807	<.001	<.001	3	1
UCEC	MIPOL1 →	-0.371	-2.668	.001	.006	3	1
UCEC	KCTD14 →	+1.187	+3.839	<.001	<.001	3	1
UCEC	CCDC3 →	-0.892	-3.438	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

RNY3P7 by OMD expression — COAD

Explore this box plot interactively →