OMD

Across TCGA cell cohorts, OMD mutation is significantly associated with the mutation status of many other genes, with 1,218 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OMD-associated genes across cancer lineages are TRMT1, TRAF3IP2, and TRPC4AP. Each is linked with OMD in more than 2 cancer types. Because this analysis shows association rather than direction, both OMD-to-partner and partner-to-OMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMT1 grouped by OMD-low versus OMD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OMD→partner) and Y-score (partner→OMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRMT1 →	+4.560	+4.309	.007	.007	1	3
BLOOD_Leukemia	TRAF3IP2 →	+5.560	+4.736	.003	.003	1	3
LARGE_INTESTINE	TRPC4AP →	+2.865	+4.217	.007	.007	1	3
LARGE_INTESTINE	GIT1 →	+2.865	+4.217	.007	.007	1	3
BLOOD_Leukemia	FBH1 →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	P2RX4 →	+4.560	+4.309	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,218 associations by consensus.

TRMT1 by OMD expression — BLOOD_Leukemia

Explore this box plot interactively →