OMA1

Across TCGA pan-cancer cohorts, OMA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OMA1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OMA1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OMA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where OMA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.965	0.813	.010	15	view →
PDAC	OS	Median	II,III,IV	0.968	0.697	.012	14	view →
GBM	DFS	Median	All	0.642	0.788	.007	7	view →
CCRCC	DFS	Tertile	All	1.000	0.570	.024	4	view →
LSCC	OS	Tertile	All	1.000	0.725	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OMA1–HNSC (OS)

Open the HNSC breakdown →