OMA1

Across TCGA patient cohorts, OMA1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OMA1-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with OMA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OMA1-to-partner and partner-to-OMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OMA1-low versus OMA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OMA1→partner) and Y-score (partner→OMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.639	+1.807	.005	.027	3	3
UCEC	Caspase-7-cleavedD198 →	+0.561	+2.341	.022	.019	3	2
UCEC	14-3-3_beta →	-0.087	-2.973	.037	.035	3	1
UCEC	Fibronectin →	-0.320	-2.449	.019	.019	3	1
UCEC	IGFBP2 →	-0.742	-2.459	.005	.019	3	1
UCEC	NF-kB-p65_pS536 →	-0.427	-2.990	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Cyclin-B1 by OMA1 expression — UCEC

Explore this box plot interactively →